Maximum likelihood refinement of electron microscopy data with normalization errors
نویسندگان
چکیده
منابع مشابه
Fast maximum-likelihood refinement of electron microscopy images
MOTIVATION Maximum-likelihood (ML) image refinement is a promising candidate to improve attainable resolution limits in 3D-EM. However, its large CPU requirements may prohibit application to 3D-structure optimization. RESULTS We speeded up ML image refinement by reducing its search space over the alignment parameters. Application of this reduced-search approach to a cryo-EM dataset yielded pr...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2009
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2009.02.007